1. Role of the Unfolded Protein Response in Regulating the Mucin ...
The signaling mucin Msb2p regulates the Cdc42p-dependent mitogen-activated protein kinase (MAPK) pathway that controls filamentous growth in yeast.
Signaling mucins are evolutionarily conserved regulators of signal transduction pathways. The signaling mucin Msb2p regulates the Cdc42p-dependent mitogen-activated protein kinase (MAPK) pathway that controls filamentous growth in yeast. The cleavage ...
2. [PDF] History 398th Engineer Regiment
Jan 24, 2024 · There was a uniform manner of saluting-which later shifted to anything from a "Hiawatha horizon-scanning" rit- ual to what may be best described ...
3. L1CAM from human melanoma carries a novel type of N-glycan ...
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Dramatic changes in glycan biosynthesis during oncogenic transformation result in the emergence of marker glycans on the cell surface. We analysed the N-linked glycans of L1CAM from different stages of melanoma progression, using high-performance liquid ...
4. [PDF] Setblebem, pa., flovember, 1919. - Moravian College
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5. [PDF] IMT Nuremberg Archives International Court of Justice - Stacks
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6. [PDF] DOCUMENT RESUME The Future of Libraries in Human Communication
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7. [PDF] FAHITIERS .EVDCIJEES A~D
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8. Identification of GlcNAcylated alpha-1-antichymotrypsin as an ...
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Non-small-cell lung cancer (NSCLC) is the main type of lung cancer with high mortality rates in worldwide. There is a need to identify better biomarkers to detect NSCLC at an early stage as this will improve therapeutic effect and patient survival rates. Two lectins (AAL/AAGL and AAL2/AANL), which specifically bind to tumour-related glycan antigens, were first used to enrich serum glycoproteins from the serum of early NSCLC patients, benign lung diseases subjects and healthy individuals. The samples were investigated by using iTRAQ labelling and LC-MS/MS. A total of 53 differentially expressed proteins were identified by quantitative proteomics and four glycoproteins (AACT, AGP1, CFB and HPX) were selected for further verification by western blotting. Receiver operating characteristic analysis showed AACT was the best candidate for early NSCLC diagnosis of the four proteins, with 94.1% sensitivity in distinguishing early tumour Stage (IA+IB) from tumour-free samples (healthy and benign samples, HB). The GlcNAcylated AACT was further detected by lectin-based ELISA and has better advantage in clinical application than total AACT. The GlcNAcylated AACT can effectively differentiate Stage I from HB samples with an AUC of 0.908 and 90.9% sensitivity at a specificity of 86.2%. A combination of GlcNAcylated AACT and carcinoembryonic antigen (CEA) was able to effectively differing Stage I from HB samples (AUC=0.914), which significantly improve the specificity of CEA. The combination...
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9. [PDF] Structural Transformation, Extractive Industries and Gender Equality
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10. Lectin nanoparticle assays for detecting breast cancer ... - PLOS
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Cancer antigen 15–3 (CA15-3) is widely utilized for monitoring metastatic breast cancer (BC). However, its utility for early detection of breast cancer is severely limited due to poor clinical sensitivity and specificity. The glycosylation of CA15-3 is known to be affected by BC, and therefore it might offer a way to construct CA15-3 glycovariant assays with improved cancer specificity. To this end, we performed lectin-based glycoprofiling of BC-associated CA15-3. CA15-3 expressed by a BC cell line was immobilized on microtitration wells using an anti-CA15-3 antibody. The glycosylation of the immobilized CA15-3 was then detected by using lectins coated onto europium (III)-doped nanoparticles (Eu+3-NPs) and measuring the time-resolved fluorescence of Eu. Out of multiple lectin-Eu+3-NP preparations, wheat germ agglutinin (WGA) and macrophage galactose-type lectin (MGL) -Eu3+-NPs bound to the BC cell line-dericed CA15-3 glycovariants (CA15-3Lectin). To evaluate the clinical performance of these two lectin-based assays, plasma samples from metastatic BC patients (n = 53) and healthy age-matched women (n = 20).Plasma CA15-3Lectin measurements better distinguished metastatic BC patients from healthy controls than the conventional CA15-3 immunoassay. At 90% specificity, the clinical sensitivity of the assays was 66.0, 67.9 and 81.1% for the conventional CA15-3, CA15-3MGL and CA15-3WGA assays, respectively. Baseline CA15-3MGL and CA15-3WGA were correlated to conventional baseline CA1...
11. [PDF] Influence of culture conditions on expansion and re-differentiation of ...
von allen 5 Pferden. Vergrößeruung 10x. Fig 2 Low ... On the other hand, cell yields in FCS, FES and AES ... Olonen, H. Salo, P. Lehenkari, T. Tuuri, T ...
12. [PDF] Cancer systems immunology - Semantic Scholar
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13. [PDF] UC San Diego - eScholarship
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14. Involving A Micro-organism Or Cell Membrane Bound Antigen Or ...
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Search for Involving A Micro-organism Or Cell Membrane Bound Antigen Or Cell Membrane Bound Receptor Or Cell Membrane Bound Antibody Or Microbial Lysate Patents and Patent Applications (Class 435/7.2) Filed with the USPTO
15. PDB 3gal citation summary ‹ Protein Data Bank in Europe ... - EMBL-EBI
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3gal: Structural basis for the recognition of carbohydrates by human galectin-7.